University Hospital for Anaesthesia and Intensive Care

301110 Physiology, 301212 Clinical pharmacy, 301203 Pharmacodynamics, 301304 Medical biology, 301401 Brain research, 301402 Neurobiology, 301403 Neurochemistry 302004 Anaesthesiology, 302015 Experimental surgery, 302018 Vascular surgery, 302026 Heart surg

Anaesthesiology, cardiopulmonary, coagulation, critical care medicine, emergency medicine, invasive ventilation, pain medicine, palliative care, point of care coagulation monitoring, and resuscitation

Anaesthesia and neuro-cognition
Mountain Emergency Medicine
Gynaecology and obstetrics
Pathophysiology of oxygen transport
Regional Anaesthesia
Coagulation and inflammation
Respiratory pathophysiology and invasive ventilation
Transplantation research
Translational cardiopulmonary resuscitation research
Ethics
Outcome studies
Environmental Sustainability in Anaesthesia
Participation Multicentre Studies

The department performs about 40,000 anaesthesia cases per year in 60 operating and diagnostic rooms. Being a university hospital, the department covers all surgical disciplines, is responsible for six postoperative care units, three intensive care units (general surgery, trauma and transplantation critical care units), two shock rooms, ground emergency service at two different locations (Innsbruck and Telfs), a rotor wing unit, a pain unit and an anaesthesia outpatient clinic. During the COVID-19 pandemic, the department opened an additional COVID-19 ICU facility and a COVID-19 observational unit. Additionally, our physicians have teaching responsibilities (anaesthesia classes for medical students), perform special skills trainings (first aid classes, ventilation management classes, basic and advanced life support trainings) and bedside teaching for our medical students during their mandatory anaesthesiology rotation. In addition, the University Hospital of Anaesthesia and Intensive Care operates an experimental laboratory for basic science research and a large animal experimental facility.

The University Hospital of Anaesthesia and Intensive Care covers a large variety of different activities, including all clinical aspects of anaesthesia procedures, postoperative care, intensive care medicine, emergency medicine, teaching responsibilities and various research activities.

Collaborations Anaesthesia and neuro-cognition
University Hospital of Radiology, Medical University Innsbruck, Austria
University Hospital of Neurology, Medical University Innsbruck, Austria
Institute for Physiology, Medical University Innsbruck, Austria
University Hospital for Psychiatry, Medical University Innsbruck, Austria

Collaborations Mountain Emergency Medicine
Department of Cardiac Surgery, Medical University Innsbruck, Austria

Collaborations Gynaecology and obstetrics
Department of Ophthalmology and Optometry, Medical University Innsbruck, Austria
Department of Gynaecology and Obstetrics, Medical University Innsbruck, Austria

Collaborations Pathophysiology of oxygen transport
University Hospital of Radiology, Medical University Innsbruck, Austria
Institute for Physiology, Medical University Innsbruck, Austria

Collaborations Coagulation and inflammation
Department of Internal Medicine, Rheumatology, Medical University Innsbruck, Austria
Department of Paediatrics, Medical University Innsbruck, Austria
Department of Cardiac Surgery, Medical University Innsbruck, Austria

Collaborations Respiratory pathophysiology and invasive ventilation
Department of Vascular Surgery, Medical University Innsbruck, Austria
Department of Cardiac Surgery, Medical University Innsbruck, Austria
Department of Visceral-, Transplantation- and Thorax surgery, Medical University Innsbruck, Austria

Collaborations Transplantation research
Department of Visceral-, Transplantation- and Thorax surgery, Medical University Innsbruck, Austria
Department of Cardiac Surgery, Medical University Innsbruck, Austria

Collaborations Translational cardiopulmonary resuscitation research
Department of Cardiac Surgery, Medical University Innsbruck, Austria
Department of Neurosurgery, Medical University Innsbruck, Austria
Department of Neurology, Medical University Innsbruck, Austria

Collaborations Outcome studies
National Database Outcome Research, Cornell University’s Centre for Clinical Outcome Research
Department of Internal Medicine, Medical University Innsbruck, Austria

Collaborations Environmental Sustainability in Anaesthesia
Department of Anaesthesia and Intensive Care, Medical University Innsbruck, Austria

It should be noted that all anaesthesiologists involved in research activities (including basic science and clinical research) are primarily employed as physicians and clinical care providers. Only a limited part of their regular working hours is dedicated to research activities. The total amount of so called `research time’ for each employee varies between 10% of total working hours for a first-year resident up to 40% of total working hours for a few attending physicians who have achieved certain scientific accomplishments (publications, successful grant applications, research awards). This means that the Department of Anaesthesiology and Critical Care Medicine does not employ full time researchers.
Due to the various specialty fields and topics in anaesthesiology, researchers of our Department cover many different research aspects. The following list provides an overview of the different research groups and topics of interest:

Anaesthesia and neuro-cognition

Study Group Members: Barbara Sinner, Christine Eckhardt, Marco Ronzani, Sasa Rajsic, Nicole Innerhofer

• Postoperative delirium

Postoperative delirium (POD) is a serious complication characterised by an acute mental change and fluctuation in attention and cognitive function. POD can result in chronic deterioration of the cognitive functions, postoperative cognitive dysfunction (POCD), and is also associated with increased postoperative morbidity, institutionalisation and mortality. Several risk factors for the development of POD are discussed among which comorbidity and older age were identified as one of the most important predisposing parameters. Our group examines risk factors and postoperative development by evaluating new preoperative risk factors, intraoperative anaesthetic management, biomarkers and postoperative modifications of various parameters.

Study Group Members: Vitaliy Pustilnik, Lukas Gasteiger, Wolfgang Lederer

• ASTI of 4min in electroconvulsive therapy, living on the edge

Major depression affects millions of people and up to twenty percent of patients do not respond to combined psychotherapy and antidepressive therapy. For these patients, the electroconvulsive therapy (ECT) is considered to be most effective and safe treatment option. State of the art ECT treatment is performed under general anaesthesia. The time interval between the administration of the anaesthetic to the electrical stimulation (ASTI) should be two to four minutes and is associated with better seizure quality. The depth of anaesthesia is a relevant factor that influences the quality of the seizure: light anaesthesia is associated with better ictal characteristics. EEG monitors, such as the Narcotrend (NCT), can be used to optimise the depth of anaesthesia. Aim of this study was to evaluate a new NCT-guided ECT management compared to a ECT management based on an ASTI of four minutes.

Mountain Emergency Medicine

Study Group Members: Bernd Wallner, Simon Woyke, Benedikt Treml, Frederik Eisendle, Mathias Ströhle

The research focus lies in Mountain Emergency Medicine with special emphasis on Hypothermia, including pathophysiological changes, diagnostic modalities and therapeutic as well as prognostic possibilities. The second emphasis lies in Avalanche Medicine including prevention, education and the advancement of survival probability.
Hypothermia has various detrimental consequences on the properties of platelets, platelet function, fibrinogen and all coagulation factors. Standard laboratory techniques cannot display those effects, since whole blood samples are generally reheated to 37° C before being analysed and therefore, will not reflect the in vivo situation of coagulation. Numerous aspects of the pathophysiological alterations in both humoral and cellular aspects of coagulation remain obscure. It is therefore the focus of our current research to relate the capacities of thromboelastometry (TEM), multiple-electrode aggregometry (MEA) and Real Time Live Confocal Imaging in their ability to identify and characterise the hypothermia-associated changes in coagulation.
Avalanche accidents are rather common in mountain regions throughout the world and are the cause of approximately 150 fatalities each year. The overall mortality rate is approx. 25% and chances to survive the avalanche accident are mainly determined by the degree and duration of avalanche burial, the patency of the airway, the presence of an air pocket, snow characteristics and the severity of traumatic injuries. The most common cause of death in completely buried avalanche victims is asphyxia followed by trauma. Whilst having protective properties, hypothermia accounts for a minority of deaths; however, hypothermic cardiac arrest has a favorable prognosis. Our research therefore focuses on providing new insights into the pathophysiology and on-site management of avalanche victims.

Gynaecology and obstetrics

Study Group Members: Raffaella Fantin, Stefan Jochberger

• “Point-of-care ultrasound abnormalities in early onset preeclampsia – prevalence and association between pulmonary interstitial syndrome and cardiac dysfunction, brain natriuretic peptide, and serum albumin”
• “Point-of-care ultrasound abnormalities in eclampsia – prevalence and association between pulmonary interstitial syndrome and cardiac dysfunction, brain natriuretic peptide, and serum albumin”
Preeclampsia (PE) and eclampsia remain leading causes of maternal morbidity and mortality. Preeclampsia is a complex, multisystem disease which, in its severe form, affects the cardiovascular, renal, hepatic, neurological and haematological systems. Due to the complexity of the disease, anaesthesia management for caesarean section in these patients remains challenging. Preeclampsia may be complicated by the development of eclampsia, which involves one or more seizures, which complicates anaesthesia and obstetrics management and requires urgent admission and delivery.
This study plans to describe the prevalence of pulmonary (PIS), cardiac and optic nerve sheath abnormalities found on ultrasound in women diagnosed with early onset preeclampsia or eclampsia. The primary aim of the current study is to examine the association between PIS, as identified by lung ultrasound, and cardiac dysfunction on echocardiography and BNP in women with early onset preeclampsia or eclampsia. For this purpose, a comprehensive echocardiographic assessment (Point-of-care ultrasound, POCUS) will be performed. The secondary aims are to explore the association between PIS or optic nerve sheath diameter (ONSD) and serum albumin. These findings will be compared with POCUS abnormalities demonstrated in our recent study on late onset PE. In addition, the association will be explored between POCUS abnormalities and CTG abnormalities and early delivery.

• Evaluation of optical coherence tomography to detect raised intracranial pressure in patients with pre-eclampsia”
Preeclampsia is an obstetric disorder and causes significant maternal and perinatal morbidity and mortality. This multisystem disease may affect the cardiovascular, renal, hepatic, neurological and haematological systems. Ultrasonography of the optic nerve sheath diameter (ONSD) can be used to evaluate increased intracranial pressure (ICP) in severe preeclampsia. Although it is a non-invasive tool and quick to perform, there is a high individual variability depending on the examiner. In this study, optic coherence tomography (OCT) will be used to observe the retina’s distinctive layers and examine the optic nerve. It is a non-invasive technique using light waves to take cross-section pictures with highest accuracy. The aim of this study is to detect changes of the optic nerve and the peripapillary retina in women with preeclampsia.

Pathophysiology of oxygen transport

Experimental Study Group Members: Benedikt Treml, Sasa Rajsic, Axel Kleinsasser, Robert Breitkopf, Corinna Velik-Salchner

• Haemorrhagic Shock: Blood Marker Sequencing and Pulmonary Gas Exchange
How characteristical blood markers of haemorrhage change over time has not yet been studied. In an animal experiment (performed some 15 years ago) we studied how haemoglobin concentration, lactate, blood glucose and base deficit was increased or decreased following a 60% loss of blood volume.
• Extravascular lung water after 48 hours at high altitude
14 subjects will be subjected to high altitude for 48 hours. Ultrasound of the lungs, the heart and the optical nerve will be performed.

Experimental Study Group Members: Simon Woyke, Christopher Rugg, Mathias Ströhle, Marco Ronzani

• Quantification of clinically relevant drug induced changes in HbO2 affinity
Drugs that are commonly used in patients suffering hypoxemia were investigated regarding their effects on haemoglobin oxygen transport. Blood samples from healthy volunteers were exposed to prostacyclins (iloprost and epoprostenol) and volatile anaesthetics in-vitro, while haemoglobin oxygen affinity was quantified by a high-throughput method for oxygen dissociation curve determination.
• Determination of the Oxygen Dissociation Curve under the Conditions of an Avalanche Burial with an Air Pocket
In a complete avalanche burial with an air pocket the Triple H Syndrome, a specific combination of hypoxia, hypercapnia and hypothermia, may arise. Carbon dioxide and temperature are known effectors of the haemoglobin oxygen dissociation curve. Venous blood samples from 15 female and 15 male subjects were exposed to 20 combinations of 4 different levels of PCO2 and 5 different temperature levels and haemoglobin oxygen affinity was quantified by a high-throughput method for oxygen dissociation curve determination. PCO2 and temperature had tremendous effects on Hb-O2 affinity, while there was a significant interaction of both effects.
• Gas-flow chamber for photometric measurements
A novel method for oxygen affinity measurement, PCT patent pending, was further elaborated. Particularly the usability and robustness of the method were improved.

Clinical Study Group Members: Lukas Gasteiger, Marco Ronzani, Simon Woyke, Christopher Rugg

To investigate changes in the oxygen dissociation curve in patients undergoing liver transplantation
• Oxygen Dissociation Curve in patients undergoing liver transplantation

Regional Anaesthesia

Study Group Members: Lukas Gasteiger, Ottokar Stundner, Elisabeth Hoerner, Anna Fiala, Markus Mittermayr, Bernd Wallner, Andreas Schlager, Günther Putz

To investigate effects of Regional Anaesthesia on the postoperative pain management and Quality of Recovery in patients undergoing cardiothoracic surgery. We also investigate pharmacological behaviour of Local Anaesthesia when mixed with adjuvants.

• The impact of PECS II blockade in patients undergoing minimal invasive cardiac surgery on postoperative opioid consumption– A prospective, randomised, controlled and triple-blinded trial
• The impact of Regional Anaesthesia (PECS Block II) versus Local Anaesthesia on the QoR-15 in patients undergoing implantation of sub-pectoral internal cardioverter device – A prospective, randomised, controlled trial
• Crystallisation of short and intermediate acting local anaesthetics when mixed with adjuvants: a semi-quantitative light microscopy analysis

Coagulation and inflammation

Study Group Members: Nicole Innerhofer, Judith Martini, Sasa Rajsic, Corinna Velik-Salchner

• Platelet and complement activation in cardiac surgery (PAC) – clinPHD Thesis
• PAC and hyper-inflammatory response
• PAC and postoperative delirium
In cardiac surgery, postoperative bleeding complications are still a major cause for morbidity and mortality. One major contributing factor is the loss of platelets and impaired platelet function. During a cardiopulmonary bypass (CPB), blood comes in close contact with foreign surfaces which induces a series of reactions; especially the complement system as part of the innate immunity is highly activated. Due to the strong crosslink between complement system, platelet function and the plasmatic coagulation it is likely that complement activation during CPB has an impact on the overall process of clot formation. In addition to the activation of the complement system, there is growing evidence that the occurrence of mitochondrial DNA (mtDNA) during CPB may be related to further platelet activation. Activated platelets may enhance micro-thrombosis, leading to organ failure and thereby contributing to postoperative morbidity.
In the PAC study, we assess the correlation between platelet function and complement activation and their impact on hyper-inflammation, postoperative bleeding, development of delirium, single organ failure and overall clinical outcome.

Respiratory pathophysiology and invasive ventilation

Experimental Study Group Members: Patrick Spraider, Julia Abram, Judith Martini, Julian Wagner, Gabriel Putzer, Simon Mathis

Our group investigates flow-controlled ventilation (FCV) as a novel ventilation method established to guarantee a continuous, constant and typically identical flow during inspiration and expiration. The constant flow coupled with direct intratracheal pressure measurement also allows an accurate evaluation of dynamic compliance and ventilation settings can be adjusted accordingly. Our first experimental pilot study demonstrated a more efficient gas exchange and improved oxygenation in individualised FCV compared to best standard of care pressure-controlled ventilation (PCV) during long term ventilation. Similar results could be observed in an experimental model of one-lung ventilation and one of acute respiratory distress syndrome. Two clinical ventilation studies are currently being performed in patients undergoing cardiac surgery and thoracic surgery with one lung ventilation, comparing individualised FCV to standard of care PCV.

• Testing of a new hemostyptic (polyphosphate gauze) for self- and companion-assistance and effect of induced haemorrhagic shock on various organ systems in a porcine model.
• Individualised flow-controlled versus pressure-controlled ventilation in a porcine model of intra-abdominal hypertension – a randomised, controlled experimental study.
• Individualised flow-controlled ventilation versus pressure-controlled ventilation in a porcine model of thoracic surgery requiring one-lung ventilation: A laboratory study.
• Individualised flow-controlled versus pressure-controlled ventilation in a porcine oleic acid-induced acute respiratory distress syndrome model.
• Short time effects of compliance guided flow-controlled ventilation versus standard of care pressure-controlled ventilation – a prospective porcine trial.
• Improved ventilation efficiency due to continuous gas flow compared to decelerating gas flow in mechanical ventilation – results of a porcine trial.

Clinical Study Group Members: Patrick Spraider, Julia Abram, Judith Martini, Lukas Gasteiger, Hannes Dejaco, Markus Mittermayr

• Flow controlled ventilation versus pressure controlled ventilation in cardiac surgery after cardiopulmonary bypass without ventilation – a prospective, randomised clinical study
• Flow controlled ventilation versus pressure controlled ventilation in thoracic surgery with one lung ventilation – a prospective, randomised clinical study
• Evaluation of tracheal pressure during continuous positive airway pressure ventilation – a prospective, clinical trial
• Driving Pressure During General Anaesthesia for Open Abdominal Surgery (DESIGNATION) – a Randomized Controlled Trial
• Driving Pressure During General Anaesthesia for Minimally Invasive Abdominal Surgery (GENERATOR) – a Randomized Clinical Trial

Transplantation research

Experimental Study Group Members: Simon Mathis, Gabriel Putzer, Judith Martini, Nikolai Staier, Julian Wagner

• Pharmacokinetics of anti-infective drugs during normothermic machine perfusion of the liver
• Normothermic (long-term) machine perfusion of the liver in a porcine model.
• Characterization of ischemia-reperfusion injury after normothermic machine perfusion.

During normothermic machine perfusion, contamination of the graft with bacteria and fungi needs to be prevented. Therefore, antibiotics are added to the perfusion solution. Due to the lack of renal elimination and the low volume of distribution, a variety of questions arise regarding the dosing interval and dose of the applied drugs. In an experimental set-up, perfusate levels, tissue levels and levels of anti-infectives in the bile fluid are measured to enable safe perfusion of the organ.

• Hearts donated after circulatory death: Impact of different heart resuscitation strategies.

Clinical Study Group Members: Simon Mathis, Gabriel Putzer, Judith Martini

• Glycocalyx damage during normothermic graft perfusion in orthotopic liver transplantation – a pilot study

By measuring the glycocalyx components syndecan-1 and heparan sulphate in the perfusate during normothermic machine perfusion, the extent of glycocalyx damage will be quantified. In addition, the influence of glycocalyx damage on the peri- and postoperative course of the recipient will be investigated. By measuring the glycocalyx components syndecan-1 and heparan sulphate in the perfusate during normothermic machine perfusion, the extent of glycocalyx damage will be quantified. Furthermore, the influence of glycocalyx damage on the peri- and postoperative course of the recipient will be investigated. However, if glycocalyx damage proves to be a factor in the occurrence of complications in the recipient of the graft, methods for optimising the perfusate will be evaluated.

• Inflammation during normothermic machine perfusion of the liver and influence on the transplant recipient

This project investigates the relationship between inflammation during normothermic machine perfusion of the liver and the perioperative course of the recipient. First results show a clear correlation between interleukin-6 levels in the perfusate during organ perfusion and the haemodynamic of the recipient. Additional cytokines will now be measured during machine perfusion and their influence on the recipient’s perioperative morbidity will be evaluated.

Translational cardiopulmonary resuscitation research

Experimental Study Group Members: Gabriel Putzer, Judith Martini, Simon Mathis, Bernd Wallner, Julia Abram, Patrick Spraider, Julian Wagner, Jonas Dunz

The poor outcome after cardiac arrest is mainly caused by irreversible brain damage during cardiopulmonary resuscitation (CPR). The brain tolerance for hypoxia is extremely low, and situations of low flow or no flow as during CPR can lead to a rapidly progressing oxygen debt resulting in brain metabolic shutdown and cell death. The main research focus of this group is to investigate mechanisms capable of increasing oxygen availability for the brain during CPR. Especially the effect of vasopressors on cerebral perfusion pressure and oxygen delivery to the brain has been controversially discussed in the literature. Adrenalin, which has been used during CPR for decades, has been accused to deteriorate microvascular perfusion due to strong vasoconstriction leading to poor oxygenation of downstream tissues. Recent results of this research group challenge this hypothesis by using a complex neuro-monitoring model in pigs including not only oxygenation parameters but also direct microvascular perfusion measurements and metabolic profiles.

• Detection of spontaneous spreading depolarisations during CPR and return of spontaneous circulation.
• Effects of head-up compared to supine position on cerebral during advanced life support in pigs.
• Effect of upper body elevation compared with flat positioning on cerebral microcirculation, cerebral oxygenation and cerebral metabolism after cardiac arrest and recovery of spontaneous circulation.
• Effects of individualised adrenaline administration compared with standard bolus administration on cerebral microcirculation, cerebral oxygenation, and cerebral metabolism during CPR in a porcine model.
• Survival and outcome of potential ECPR patients in Innsbruck.

Clinical Study Group Members: Benedikt Treml, Sasa Rajsic, Axel Kleinsasser

Mortality and complications during ECLS remain high. We seek to investigate the clinical outcome of patients requiring ECMO support. Furthermore, we are interested in a deeper understanding of the manifold interactions of hypobaric and normobaric hypoxia.

Clinical Study Group Members: Janett Kreutziger, Benedikt Treml, Christopher Rugg

• Blood glucose and success of cardiopulmonary resuscitation (CPR) – is there an association?
o Success of CPR in OHCA in dependency on initial blood glucose
o Success of CPR in IHCA in dependency on initial blood glucose

Ethics

Study Group Members: Barbara Friesenecker

Main Working Area in Ethics research and Teaching:
• Overtreatment and its consequences
• Difficult end of life decisions
• Assisted Suicide
• Triage
• Mandatory Vaccination

Projects:
• Competence oriented ethics teaching at the Medical University of Innsbruck (Diploma Thesis)
• Factors influencing the access to palliative care from the view of inter-professional ICU teams (Master Thesis)

Outcome Studies

Study Group Members: Lukas Gasteiger, Helmut Raab, Ottokar Stundner, Thomas Senoner, Raffaella Fantin, Christoph Frisch, Willi Tröger

• High Intensity PreHab before Major Abdominal Surgery – A controlled, single blinded, randomised study

To investigate effects of individualised high intensity preoperative fitness training on the Quality of Recovery in patients undergoing major abdominal surgery.

Study Group Members: Petra Hillinger

• Implementation of a clinical screening and management system for perioperative myocardial infarction/injury after non-cardiac surgery: Feasibility and medical economic impact.

Study Group Members: Lukas Gasteiger, Gabriel Putzer, Judith Martini, Julia Abram

• Effects of Covid-19 on surgical procedures (Gasteiger, Putzer, Martini, Abram)

Study Group Members: Janett Kreutziger, Christopher Rugg

• Stress hyperglycaemia in COVID-19 patients

Prognostic relevance of stress hyperglycaemia regarding outcome (survival, hospital and intensive care length of stay, association of stress hyperglycaemia with laboratory parameters, influence of medication, alimentation and infection on the course of hyperglycaemia

Environmental Sustainability in Anaesthesia

Study Group Members: Janett Kreutziger, Ruth Kröss

• Energy consumption of the anaesthetic gas scavenging system
• Feasibility, safety and efficiency of an anaesthetic gas scavenging system (Contrafluran®) during Sedaconda sedation during intensive care
• Online survey about environmental sustainability provision in Austrian hospitals from the view of trainees in anaesthesia and intensive care

Participation Multicentre Studies

• FRAilty incidence in surGIcal European patients (FRAGILE) European prospective cohort study of prevalence of frailty in surgical patients (Gabriel Putzer)
• In vitro studies to test leukocyte deletion filters (LDF) in the removal of EPCAM-positive tumour cells using catumaxomab from intraoperatively collected wound blood of tumour patients. (Judith Martini, Gabriel Putzer)
• Management and Outcomes of Perioperative Care among European Diabetic Patients (MOPED): A prospective observational, international cohort study (Gabriel Putzer)
• „Safe and Timely Antithrombotic Removal (STAR) Registry: International registry on the use of CytoSorb for removal of antithrombotic agents in the acute hospital setting“ (Judith Martini, Anna Fiala)
• ACT in Stroke (Barbara Sinner)
• ENCORE Effects of Anaesthesia in colorectal cancer outcome trial (Sasha Rajsic)
• PROBLEMS Implementation of problem oriented learning (Sasha Rajsic)

Mountain Emergency Medicine

Treml B, Wallner B, Blank C, Fries D, Schobersberger W
The Influence of Environmental Hypoxia on Hemostasis-A Systematic Review
Front Cardiovasc Med 2022;9:813550 (Impact[2021]: 5.848)
PMID: 35252392 DOI: 10.3389/fcvm.2022.813550

Wallner B, Schenk B, Paal P, Falk M, Strapazzon G, Martini WZ, Brugger H, Fries D
Hypothermia Induced Impairment of Platelets: Assessment With Multiplate vs. ROTEM-An In Vitro Study
Front Physiol 2022;13:852182 (Impact[2021]: 4.755)
PMID: 35422712 DOI: 10.3389/fphys.2022.852182

Wallner B, Putzer G, Mair P
Prognostication of cardiac arrest in avalanche victims
Resuscitation 2022 Feb;171:121-122 (Impact[2021]: 6.251)
PMID: 35131033 DOI: 10.1016/j.resuscitation.2021.12.008

Masè M, Werner A, Putzer G, Avancini G, Falla M, Brugger H, Micarelli A, Strapazzon G
Low Ambient Temperature Exposition Impairs the Accuracy of a Non-invasive Heat-Flux Thermometer
Front Physiol 2022;13:830059 (Impact[2021]: 4.755)
PMID: 35309078 DOI: 10.3389/fphys.2022.830059

Miller C, Nardelli P, Hell T, Glodny B, Putzer G, Paal P
Sex differences in appropriate insertion depth for intraosseous access in adults: An exploratory radiologic single-center study
J Vasc Access 2022 Aug 03:11297298221115412 (Impact[2021]: 2.326)
PMID: 35922960 DOI: 10.1177/11297298221115412

Gynaecology and obstetrics

Marhofer D, Jaksch W, Aigmüller T, Jochberger S, Urlesberger B, Pils K, Maier B, Likar R, Kayer B, Wallner R, Fink P, Grögl G
Pain management during pregnancy: An expert-based interdisciplinary consensus recommendation
Schmerztherapie in der Schwangerschaft : Eine expertInnenbasierte interdisziplinäre Konsensus-Empfehlung.
Schmerz 2021 Dec;35(6):382-390 (Impact[2021]: 1.629)
PMID: 34324048 DOI: 10.1007/s00482-021-00571-4

Pathophysiology of oxygen transport

Treml B; Kleinsasser, A; Knotzer, J; Breitkopf, R; Velik-Salchner, C; Rajsic, S
Hemorrhagic Shock: Blood Marker Sequencing and Pulmonary Gas Exchange.
Diagnostics 2023, 13, 639. https://doi.org/10.3390/diagnostics13040639

Woyke S, Mair N, Haller T, Ronzani M, Plunser D, Oberacher H, Gatterer H, Rugg C, Ströhle M
The impact of nebulized epoprostenol and iloprost on hemoglobin oxygen affinity: an ex vivo experiment
Am J Physiol Lung Cell Mol Physiol 2022 Jun 01;322(6):L898-L903 (Impact[2021]: 6.011)
PMID: 35503651 DOI: 10.1152/ajplung.00084.2022

Ronzani M, Woyke S, Mair N, Gatterer H, Oberacher H, Plunser D, Haller T, Ströhle M, Rugg C
The effect of desflurane, isoflurane and sevoflurane on the hemoglobin oxygen dissociation curve in human blood samples
Sci Rep 2022 Aug 10;12(1):13633 (Impact[2021]: 4.997)
PMID: 35948604 DOI: 10.1038/s41598-022-17789-6

Woyke S, Brugger H, Ströhle M, Haller T, Gatterer H, Dal Cappello T, Strapazzon G
Effects of Carbon Dioxide and Temperature on the Oxygen-Hemoglobin Dissociation Curve of Human Blood: Implications for Avalanche Victims
Front Med (Lausanne) 2021;8:808025 (Impact[2021]: 5.058)
PMID: 35198571 DOI: 10.3389/fmed.2021.808025

Regional Anaesthesia

Hoerner E, Stundner O, Putz G, Steinfeldt T, Mathis S, Gasteiger L
Crystallization of ropivacaine and bupivacaine when mixed with different adjuvants: a semiquantitative light microscopy analysis
Reg Anesth Pain Med 2022 Jun 23 (Impact[2021]: 5.564)
PMID: 35738668 DOI: 10.1136/rapm-2022-103610

Hoerner E, Gasteiger L, Ortler M, Pustilnik V, Mathis S, Brunner C, Neururer S, Schlager A, Egle D, Putz G
The impact of dexamethasone as a perineural additive to ropivacaine for PECS II blockade in patients undergoing unilateral radical mastectomy – A prospective, randomized, controlled and double-blinded trial
J Clin Anesth 2022 May;77:110622 (Impact[2021]: 9.375)
PMID: 34872040 DOI: 10.1016/j.jclinane.2021.110622

Coagulation and inflammation

Innerhofer N, Treichl B, Rugg C, Fries D, Mittermayr M, Hell T, Oswald E, Innerhofer P
First-Line Administration of Fibrinogen Concentrate in the Bleeding Trauma Patient: Searching for Effective Dosages and Optimal Post-Treatment Levels Limiting Massive Transfusion-Further Results of the RETIC Study
J Clin Med 2021 Aug 31;10(17) (Impact[2021]: 4.964)
PMID: 34501379 DOI: 10.3390/jcm10173930

Respiratory pathophysiology and invasive ventilation

Spraider P, Martini J, Abram J, Putzer G, Ranalter M, Mathis S, Hell T, Barnes T, Enk D
Individualised flow-controlled ventilation versus pressure-controlled ventilation in a porcine model of thoracic surgery requiring one-lung ventilation: A laboratory study
Eur J Anaesthesiol 2022 Nov 01;39(11):885-894 (Impact[2021]: 4.183)
PMID: 36125005 DOI: 10.1097/EJA.0000000000001745

Abram J, Spraider P, Wagner J, Mathis S, Ranalter M, Putzer G, Hell T, Barnes T, Enk D, Martini J
Short time effects of compliance guided flow-controlled ventilation versus standard of care pressure-controlled ventilation – a prospective porcine trial
Minerva Anestesiol 2023 Feb 17 (Impact[2021]: 3.396)
PMID: 36799291 DOI: 10.23736/S0375-9393.23.16949-5

Abram J, Martini J, Spraider P, Putzer G, Ranalter M, Wagner J, Glodny B, Hell T, Barnes T, Enk D
Individualised flow-controlled versus pressure-controlled ventilation in a porcine oleic acid-induced acute respiratory distress syndrome model
Eur J Anaesthesiol 2023 Feb 08 (Impact[2021]: 4.183)
PMID: 36749046 DOI: 10.1097/EJA.0000000000001807

Transplantation research

Gasteiger L, Putzer G, Unterpertinger R, Cardini B, Schneeberger S, Eschertzhuber S, Mair P
Solid Organ Donation From Brain-dead Donors With Cardiorespiratory Arrest After Snow Avalanche Burial: A Retrospective Single-center Study
Transplantation 2022 Mar 01;106(3):584-587 (Impact[2021]: 5.385)
PMID: 33859150 DOI: 10.1097/TP.0000000000003785

Putzer G, Gasteiger L, Mathis S, van Enckevort A, Hell T, Resch T, Schneeberger S, Martini J
Solid Organ Donation and Transplantation Activity in the Eurotransplant Area During the First Year of COVID-19
Transplantation 2022 Jul 01;106(7):1450-1454 (Impact[2021]: 5.385)
PMID: 35411875 DOI: 10.1097/TP.0000000000004158

Mathis S, Putzer G, Schneeberger S, Martini J
The Endothelial Glycocalyx and Organ Preservation-From Physiology to Possible Clinical Implications for Solid Organ Transplantation
Int J Mol Sci 2021 Apr 13;22(8) (Impact[2021]: 6.208)
PMID: 33924713 DOI: 10.3390/ijms22084019

Translational cardiopulmonary rescucitation research

Putzer G, Martini J, Mair P, Helbok R
Reply to: Cerebral microdialysis after cardiac arrest – Misinterpretations based on a misconception
Resuscitation 2022 Feb;171:71-72 (Impact[2021]: 6.251)
PMID: 34979162 DOI: 10.1016/j.resuscitation.2021.12.033

Rajsic S, Breitkopf R, Bukumiric Z, Treml B
ECMO Support in Refractory Cardiogenic Shock: Risk Factors for Mortality
J Clin Med 2022 Nov 18;11(22) (Impact[2021]: 4.964)
PMID: 36431298 DOI: 10.3390/jcm11226821

Rajsic S, Breitkopf R, Oezpeker UC, Bukumirić Z, Dobesberger M, Treml B
The Role of Excessive Anticoagulation and Missing Hyperinflammation in ECMO-Associated Bleeding
J Clin Med 2022 Apr 21;11(9) (Impact[2021]: 4.964)
PMID: 35566439 DOI: 10.3390/jcm11092314

Rajsic S, Treml B, Jadzic D, Breitkopf R, Oberleitner C, Popovic Krneta M, Bukumiric Z
Extracorporeal membrane oxygenation for cardiogenic shock: a meta-analysis of mortality and complications
Ann Intensive Care 2022 Oct 05;12(1):93 (Impact[2021]: 10.318)
PMID: 36195759 DOI: 10.1186/s13613-022-01067-9

Rajsic S, Breitkopf R, Jadzic D, Popovic Krneta M, Tauber H, Treml B
Anticoagulation Strategies during Extracorporeal Membrane Oxygenation: A Narrative Review
J Clin Med 2022 Aug 31;11(17) (Impact[2021]: 4.964)
PMID: 36079084 DOI: 10.3390/jcm11175147

Ethics

“Grauzonen Machen mir Angst”: Stimmen zum assistierten Suizid.
Anästhesie Nachr 4, 126–131 (2022). https://doi.org/10.1007/s44179-022-00045-7

Friesenecker, B., Stadlinger, J. Assistierter Suizid: großer Stress für Helfende. Anästhesie Nachr 4, 216–217 (2022). https://doi.org/10.1007/s44179-022-00069-z

Outcome studies

Gasteiger L, Abram J, Klein S, Tscholl P, Hell T, Putzer G, Moser B, Joannidis M, Martini J
Impact of COVID-19 on elective, emergency and oncological surgery during the first and the second wave in a tertiary university hospital : Have we learned the lessons?
Wien Klin Wochenschr 2022 Dec;134(23-24):868-874 (Impact[2021]: 2.275)
PMID: 35608675 DOI: 10.1007/s00508-022-02041-y

Abram J, Gasteiger L, Putzer G, Spraider P, Mathis S, Hell T, Martini J
Impact of COVID-19 Related Lockdown on the Frequency of Acute and Oncological Surgeries-Lessons Learned From an Austrian University Hospital
Front Public Health 2021;9:625582 (Impact[2021]: 6.461)
PMID: 34409000 DOI: 10.3389/fpubh.2021.625582

Unterpertinger R, Schmelzer P, Martini J, Putzer G, Gasteiger L, Thaler M, Hell T, Voelckel W
Emergency missions in Tyrol in spring 2020 : Influence of COVID-19-A retrospective observational study focusing on air rescue
Notärztliche Einsätze in Tirol im Frühjahr 2020 : Der Einfluss von COVID-19 – eine retrospektive Beobachtungsstudie mit Fokus Luftrettung.
Anaesthesiologie 2023 Jan;72(1):21-27
PMID: 36301309 DOI: 10.1007/s00101-022-01212-w

Anaesthesia and neurocognition

• Department of Anaesthesia, General Intensive Care and Pain Medicine, Medical University of Vienna
• Department of Anaesthesia, Technical University Munich
• Department of Anaesthesia, University of Regensburg
• University Hospital of Anaesthesia and Intensive Care Medicine, Medical University Graz, Austria

Mountain Emergency Medicine

• Giacomo Strapazzon, Institute of Mountain Emergency Medicine, Eurac Research Bolzano, Italy
• Institute for Sports Medicine, Alpine Medicine and Health Tourism, Private University for Health Sciences, Hall i.T., University Hospital Innsbruck, Innsbruck, Austria.
• U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX, United States.

Gynaecology and obstetrics

• University of Cape Town (South Africa)
• Stanford University (United States of America)

Pathophysiology of oxygen transport

• Johann Knotzer, Institute for Anaesthesiology and Intensive Care, Wels-Grieskirchen, Austria
• Giacomo Strapazzon, Institute of Mountain Emergency Medicine, Eurac Research Bolzano, Italy
• Institute for Pharmaceutical Chemistry, Graz, Austria

Respiratory pathophysiology and invasive ventilation

• Dietmar Enk, P, MD, University Hospital of Münster, Münster, Germany
• Tom Barnes, MSc, PhD, University of Greenwich, London, United Kingdom
• Prof. Dr. Marcus J Schultz, Department of Intensive Care, Amsterdam UMC, location AMC
• Prof. Dr. Markus W. Hollmann, Department of Anaesthesiology, Amsterdam UMC, location AMC

Translational cardiopulmonary resuscitation research

• Institute for Medical Statistics and Informatics, Medical University Belgrade, Serbia
• University Hospital of Anaesthesia and Intensive Care Medicine, Medical University Graz, Austria
• Department of Bioengineering, Imperial College London, UK
• German Resuscitation Register

Outcome studies

• University Hospital Basel, Department Cardiology, Cardiovascular Research Institute Basel

Environmental Sustainability in Anaesthesia

• Primar Priv.Doz. Reinhard Germann, LKH Feldkirch
• Department of Anaesthesia, General Intensive Care and Pain Medicine, Medical University of Vienna
• University Hospital of Anaesthesia and Intensive Care Medicine, Medical University Graz, Austria
• Univ.-Prof. Dr. Andreas Schlager, University Hospital of Anaesthesia and Intensive Care, Innsbruck