Paediatrics II

301401, 302049, 302060, 303009, 302032

brain injury, brain maturation, breast milk, cardiovascular risk, developmental outcome, FOXO3 modulating drugs, neonatal neuroimaging, neonatal neuroscience, and Preterm infants

Characterization of risk predictors for adverse outcomes in preterm infants

Monitoring of preterm brain maturation and diagnosis of brain injury (aEEG, GM, MRI, NIRS), biomarker identification

Investigating the effects of prematurity, neonatal growth and feeding practices on cardiovascular risk factors

Analysis of brain development and injury mechanisms and development of substances for neuroprotection and the treatment of newborn brain injury

Analysis of FOXO3-modulating drugs

The Department of Neonatology at the Medical University of Innsbruck is a perinatal centre that provides the highest possible level of care. We offer treatment for all preterm and critically ill neonates in Tyrol, including a standardized follow-up programme until age 5. We undertake a combination of basic and clinical research, aiming at the early identification of infants at risk of adverse outcome and the improvement of long-term outcomes. Our clinical research includes the characterization of neurodevelopmental and cardiovascular outcomes of very preterm infants until school age and the definition of risk predictors of adverse outcomes. We apply multimodal methods to monitor brain activity (aEEG, NIRS), brain maturation (GM) and brain injury (MRI), evaluate the role of nutrition/growth and study the optimization of perinatal resuscitation (e.g. stabilization of the preterm infant before umbilical cord clamping). In combination with clinical research, we are evaluating laboratory biomarkers to obtain a better understanding of brain development and injury mechanisms, to diagnose brain injury and to predict long-term outcomes. We participate in a worldwide collaboration for quality improvement – the Vermont Oxford Network – with the aim of following key neonatal outcomes and continuously improving patient care. We have close national and international collaborations with perinatal centres and with local neuroscience and cardiovascular science groups.

Improvements in neonatal intensive care medicine in recent decades have substantially reduced preterm infant mortality. However, infants born prematurely remain at a high risk of neurodevelopmental delay and lifelong handicap. There are no causal therapeutic strategies for neonatal brain injury, so clinical management focuses on optimal perinatal care and on the early identification of infants at a high risk of adverse outcomes.

Clinical Research Projects

Neonatal Neuroscience

Gande N., Griesmaier E., Hammerl M., Hochmayr C., Höck M., Messner A., Mitterer W., Müller K., Neubauer V., Pupp Peglow U., Posod A., Sappler M., Schreiner C., Staudt A., Winkler I., Kiechl-Kohlendorfer U.

Evaluation of brain maturation, brain injury and neurodevelopmental outcome

To improve the neurodevelopmental prognosis in preterm and critically ill neonates, we use an integrative approach that combines clinical parameters, electrophysiological monitoring and advanced imaging techniques. Our multidimensional strategy provides a comprehensive assessment of brain development and of the risks of neurological impairments. With a combination of amplitude-integrated electroencephalography (aEEG), cerebral ultrasound (cUS), near-infrared spectroscopy (NIRS), general movements assessment (GMA) and magnetic resonance imaging (MRI)

we are investigating diagnostic tools to enhance the prediction of short- and long-term outcomes. By incorporating clinical variables (gestational age, birth weight, gender, cytomegalovirus infection, medication) into this diagnostic toolkit, we aim to identify markers that are predictive of later developmental outcomes.

Cardiovascular Science

Cardiovascular Follow-Up of Very Preterm Infants (NeoVasC)

Mitterer W., Hochmayr C., Posod A., Neubauer V., Griesmaier E., Kiechl-Kohlendorfer U.

Prematurity is an established risk factor for cardiovascular disease in adult life. The early detection of cardiovascular risk predictors is crucial for effective prevention programmes. Our research group is assessing both traditional and novel cardiovascular risk factors from birth until preschool age, focusing in particular on the protective effect of exclusive human milk feeding on cardiovascular risk.

Early Vascular Ageing in YOUth (EVA4YOU)

Messner A., Nairz J., Hochmayr C., Gande N., Staudt A., Kiechl-Kohlendorfer U.

The EVA4YOU study builds on the knowledge gained from the EVA study. It aims to improve the vascular health of 15/16-year-old Tyrolean pupils and apprentices and to elucidate the mechanisms of early vascular ageing. We are investigating the impact of prematurity, neonatal growth characteristics and feeding practices on early vascular ageing and hope to elucidate the associations with additional risk markers for cardiovascular diseases.

Experimental Research Projects

Neonatal Research Laboratory

Posod A., Griesmaier E., Winkler I., Hochmayr C., Mayer E., Huber E., Urbanek M.

The Neonatal Research Laboratory is advancing the understanding and management of neonatal health, with a particular emphasis on brain development, injury mechanisms and the identification of biomarkers. Our interdisciplinary approach combines fundamental research and clinical studies to address critical challenges in neonatal care.

Major research topics:

• Neonatal brain injury
• Exploring the mechanisms and consequences of neonatal brain injury, including encephalopathy of prematurity and hypoxic-ischemic encephalopathy. We use various in vivo and in vitro models to assess neuroprotective and therapeutic strategies to mitigate injury and promote recovery

  

  

• Clinical research on biomarker discovery to improve the diagnosis, prognosis and personalized care for neonates.
• Breast milk and immunological health
• Examining the complex composition of breast milk and its potential protective properties. We are exploring a range of bioactive components, such as antibodies and immunoregulatory molecules, to understand their roles in neonatal development and resilience.
• Identifying cardiovascular and neurological biomarkers to evaluate risks and long-term outcomes in very preterm infants, with a particular focus on early childhood stages.
• Oxygen Dissociation Curve (ODC)
• Exploring ODC shifts in perinatal asphyxia and preterm infants to understand the impact of foetal haemoglobin on oxygen delivery and neonatal outcomes.

Our work bridges basic research and clinical applications, contributing to improved outcomes for the most vulnerable neonatal populations.

Pharmacological inhibition of the transcription factor FOXO3

In neuroblastoma, an aggressive childhood tumour, cancer stem cells initiate treatment failure. The transcription factor FOXO3, a regulator of cancer stem-cell maintenance, triggers migration, autophagy and chemoresistance in high-stage neuroblastoma. We are investigating the impact on cancer stem cells and on therapy-resistant tumour cells of the pharmacological inhibition of FOXO3 by small molecular weight compounds.

Clinical Research Projects

Neonatal Neuroscience

Griesmaier E, Hammerl M, Sappler M, Zimmermann M, Gande N, Winkler I, Kiechl-Kohlendorfer U, Neubauer V. Growth and cognitive outcome in very preterm infants with postnatal cytomegalovirus infection. NEONATOLOGY. 2024 Dec 11:1-14; [Epub ahead of print]; PubMed: 39662062 doi: 10.1159/000542820

Sappler, Maria; Neubauer, Vera; Posod, Anna; Schreiner, Christina; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke: Early Brain Activity in Very Preterm Infants of Mothers with Gestational Diabetes Mellitus: A Pilot Study. NEONATOLOGY. 2024; 121(3); 342-350. PubMed: 38346405 doi: 10.1159/000536182

Schreiner, Christina; Staudt, Anna; Neubauer, Vera; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke: Amplitude-integrated electroencephalography showed alterations in cerebral activity in monochorionic twins with twin-to-twin transfusion syndrome. ACTA PAEDIATRICA. 2024; [Epub ahead of print]; PubMed: 39652525 doi: 10.1111/apa.17532

Winkler, Ira; Sappler, Maria; Gizewski, Elke Ruth; Kiechl-Kohlendorfer, Ursula; Neubauer, Vera; Griesmaier, Elke: Relationship between Brain Function and Microstructural Brain Maturation in Preterm Infants. NEONATOLOGY. 2024; 121(2); 213-221. PubMed: 38052194 doi: 0.1159/000535042

Pichler, Gerhard; Goeral, Katharina; Hammerl, Marlene; Perme, Tina; Dempsey, Eugene M.; Springer, Laila; Lista, Gianluca; Szczapa, Tomasz; Fuchs, Hans; Karpinski, Lukasz; Bua, Jenny; Avian, Alexander; Law, Brenda; Urlesberger, Berndt; Buchmayer, Julia; Kiechl-Kohlendorfer, Ursula; Kornhauser-Cerar, Lilijana; Schwarz, Christoph E.; Gruendler, Kerstin; Stucchi, Ilaria; Schwaberger, Bernhard; Klebermass-Schrehof, Katrin; Schmoelzer, Georg M.; Cosgod III Study Grp: Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): multicentre randomised phase 3 clinical trial. BMJ-BRITISH MEDICAL JOURNAL. 2023; 380; e072313.

Engel, V.; Mauron-Papadimitriou, V.; Bührer, L.; Ebner, L.; Keller, L.; Gosteli, M.; Siegfried, S.; Latal, B.; Kiechl-Kohlendorfer, U.; Held, U.: Transition to home after very preterm birth: improving outcomes of children and their families-a systematic review protocol.
BMJ OPEN. 2024; 14(12); e090155.
PubMed: 39806642 doi: 10.1136/bmjopen-2024-090155 [FLDID: 144190] IF: 2.400 (2023) / ZIT: 0

Griesmaier, Elke; Schreiner, Christina; Winkler, Ira; Posod, Anna; Sappler, Maria; Kiechl-Kohlendorfer, Ursula; Neubauer, Vera: Association of aEEG and brain injury severity on MRI at term-equivalent age in preterm infants.
ACTA PAEDIATRICA. 2024; 113(2); 229-238.
PubMed: 37897122 doi: 10.1111/apa.17017 [FLDID: 140785] IF: 2.400 (2023) / ZIT: 2

Kiechl-Kohlendorfer, Ursula; Simma, Burkhard; Berger, Angelika; Urlesberger, Berndt; Wald, Martin; Haiden, Nadja; Fuiko, Renate; Ndayisaba, Jean-Pierre; Austrian Preterm Outcome Study Grp: Two-year neurodevelopmental outcome in extremely preterm-born children: The Austrian Preterm Outcome Study Group.
ACTA PAEDIATRICA. 2024; 113(6); 1278-1287.
PubMed: 38433292 doi: 10.1111/apa.17187 [FLDID: 142803] IF: 2.400 (2023) / ZIT: 3

Meyer, S.; Bay, J.; Franz, AR.; Ehrhardt, H.; Klein, L.; Petzinger, J.; Binder, C.; Kirschenhofer, S.; Stein, A.; Hüning, B.; Heep, A.; Cloppenburg, E.; Muyimbwa, J.; Ott, T.; Sandkötter, J.; Teig, N.; Wiegand, S.; Schroth, M.; Kick, A.; Wurm, D.; Gebauer, C.; Linnemann, K.; Kittel, J.; Wieg, C.; Kiechl-Kohlendorfer, U.; Schmidt, S.; Böttger, R.; Thomas, W.; Brevis Nunez, F.; Stockmann, A.; Kriebel, T.; Müller, A.; Klotz, D.; Morhart, P.; Nohr, D.; Biesalski, HK.; Giannopoulou, EZ.; Hilt, S.; Poryo, M.; Wagenpfeil, S.; Haiden, N.; Ruckes, C.; Ehrlich, A.; Gortner, L.; NeoVitaA trial investigators [Schmid, A.; Pellkofer, Y.; Griesmaier, E.]: Early postnatal high-dose fat-soluble enteral vitamin A supplementation for moderate or severe bronchopulmonary dysplasia or death in extremely low birthweight infants (NeoVitaA): a multicentre, randomised, parallel-group, double-blind, placebo-controlled, investigator-initiated phase 3 trial.
LANCET RESPIRATORY MEDICINE. 2024; 12(7); 544-555.
PubMed: 38643780 doi: 10.1016/S2213-2600(24)00073-0 [FLDID: 144471] IF: 38.700 (2023) / ZIT: 6

Neubauer, Vera; Gande, Nina; Winkler, Ira; Posod, Anna; Schreiner, Christina; Hammerl, Marlene; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke: Postnatal cytomegalovirus infections did not alter amplitude-integrated electroencephalography signals or general movements in preterm infants.
ACTA PAEDIATRICA. 2024; [Epub ahead of print];
PubMed: 39300940 doi: 10.1111/apa.17430 [FLDID: 143392] IF: 2.400 (2023) / ZIT: 0

Schreiner, Christina; Staudt, Anna; Neubauer, Vera; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke: Amplitude-integrated electroencephalography showed alterations in cerebral activity in monochorionic twins with twin-to-twin transfusion syndrome.
ACTA PAEDIATRICA. 2024; [Epub ahead of print];
PubMed: 39652525 doi: 10.1111/apa.17532 [FLDID: 143673] IF: 2.400 (2023) / ZIT: 0

Stuikiene, Kristina; Griesmaier, Elke; Aldakauskiene, Ilona; Garcinskiene, Jurgita; Paskauske, Marija; Smigelskas, Kastytis; Rimdeikiene, Inesa; Marmiene, Vitalija; Tameliene, Rasa: The Predictive Value of Amplitude-Integrated Electroencephalography for the Neurodevelopmental Outcomes of Preterm Newborns at 12 Months Corrected Age.
CHILDREN. 2024; 11(8); 979.
PubMed: 39201913 doi: 10.3390/children11080979 [FLDID: 143556] IF: 2.000 (2023) / ZIT: 0

Stuikiene, Kristina; Griesmaier, Elke; Aldakauskiene, Ilona; Vidmante, Regina; Smigelskas, Kastytis; Tameliene, Rasa: Trends in Amplitude-Integrated Electroencephalography in the Smallest Preterm Neonates.
CHILDREN. 2024; 11(5); 566.
PubMed: 38790561 doi: 10.3390/children11050566 [FLDID: 142210] IF: 2.000 (2023) / ZIT: 1

Wolfsberger, Christina H.; Schwaberger, Bernhard; Urlesberger, Berndt; Avian, Alexander; Goeral, Katharina; Hammerl, Marlene; Perme, Tina; Dempsey, Eugene M.; Springer, Laila; Lista, Gianluca; Szczapa, Tomasz; Fuchs, Hans; Karpinski, Lukasz; Bua, Jenny; Law, Brenda; Buchmayer, Julia; Kiechl-Kohlendorfer, Ursula; Kornhauser-Cerar, Lilijana; Schwarz, Christoph E.; Grundler, Kerstin; Stucchi, Ilaria; Klebermass-Schrehof, Katrin; Schmolzer, Georg M.; Pichler, Gerhard; COSGOD III Study Grp [Schreiner, Christina; Griesmaier, Elke; Neubauer, Vera; Wöckinger, Peter; Posod, Anna]: Reference Ranges for Arterial Oxygen Saturation, Heart Rate, and Cerebral Oxygen Saturation during Immediate Postnatal Transition in Neonates Born Extremely or Very Preterm.
JOURNAL OF PEDIATRICS. 2024; 273; 114132.
PubMed: 38823628 doi: 10.1016/j.jpeds.2024.114132 [FLDID: 143833] IF: 3.900 (2023) / ZIT: 0

Wolfsberger, Christina Helene; Schwaberger, Bernhard; Urlesberger, Berndt; Scheuchenegger, Anna; Avian, Alexander; Hammerl, Marlene; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke; Pichler, Gerhard: Cerebral oxygenation during immediate fetal-to-neonatal transition and fidgety movements between six to 20 weeks of corrected age: An ancillary study to the COSGOD III trial.
EUROPEAN JOURNAL OF PEDIATRICS. 2024; 183(10); 4425-4433.
PubMed: 39126518 doi: 10.1007/s00431-024-05711-3 [FLDID: 143617] IF: 3.000 (2023) / ZIT: 0

Berger, Angelika; Simma, Burkhard; Kiechl-Kohlendorfer, Ursula; Urlesberger, Berndt; Wald, Martin; Csillag, Bernhard; Badinger-Sobotka, Barbara; Kletecka-Pulker, Maria; Salzer, Hans: Recommendations for the care of extremely premature infants at the border of viability: Joint recommendations of the Working Group Neonatology and Pediatric Intensive Care (AG NPI) of the Austrian Society for Pediatrics and Adolescent Medicine (ÖGKJ) and the Institute for Ethics and Law in Medicine of the University of Vienna (IERM) updated 2024.
MONATSSCHRIFT KINDERHEILKUNDE. 2024; [Epub ahead of print];
doi: 10.1007/s00112-024-02066-9 [FLDID: 143688] IF: .300 (2023) / ZIT: 0

Berger, Angelika; Simma, Burkhard; Kiechl-Kohlendorfer, Ursula; Urlesberger, Berndt; Wald, Martin; Wald, Martin; Csillag, Bernhard; Badinger-Sobotka, Barbara; Kletecka-Pulker, Maria; Salzer, Hans: Clinical Decision-Making for Premature Infants at the Border of Viability.
MONATSSCHRIFT KINDERHEILKUNDE. 2024; 172(12); 1085-1088.
doi: 10.1007/s00112-024-02085-6 [FLDID: 143418] IF: .300 (2023) / ZIT: 0

Hochmayr, Christoph; Auckenthaler, Michael; Fink, Franz-Martin; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke: Differential diagnosis of blue toes in a newborn baby: might have been maternal infection with COVID-19?
LANCET. 2023; 401(10384); E20-E20.
PubMed: 37061270 doi: 10.1016/S0140-6736(23)00335-5 [FLDID: 137359] IF: 98.400 (2023) / ZIT: 2

Hochmayr, Christoph; Hammerl, Marlene; Winkler, Ira; Schweigmann, Gisela; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke; Posod, Anna: Striatal Lacunar Infarction in a Late Preterm Infant Born to a Mother with Active Peripartum SARS-CoV-2 Infection.
CASE REPORTS IN PEDIATRICS. 2023; 2023; 1611451.
PubMed: 37810175 doi: 10.1155/2023/1611451 [FLDID: 139313] IF: .700 (2023) / ZIT: 0

Winkler, Ira; Steichen, Elisabeth; Kapelari, Klaus; Wöckinger, Peter; Neubauer, Vera; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke: Pituitary Stalk Interruption Syndrome – Clinical Presentation and Management of a Potentially Life-threatening Disease in Newborns.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY. 2023; [Epub ahead of print];
PubMed: 37074078 doi: 10.4274/jcrpe.galenos.2023.2023-1-23 [FLDID: 141171] IF: 1.500 (2023) / ZIT:

Hoeck, Michaela; Sappler, Maria; Hammerl, Marlene; Griesmaier, Elke; Ndayisaba, Jean-Pierre; Schreiner, Christina; Pupp-Peglow, Ulrike; Kiechl-Kohlendorfer, Ursula; Neubauer, Vera: Prophylactic low-dose paracetamol for ductal closure and neurodevelopmental outcome in very preterm infants.
ACTA PAEDIATRICA. 2023; 112(8); 1706-1714.
PubMed: 37103481 doi: 10.1111/apa.16806 [FLDID: 139544] IF: 2.400 (2023) / ZIT: 3

Pellkofer, Yasmin; Hammerl, Marlene; Griesmaier, Elke; Sappler, Maria; Gizewski, Elke Ruth; Kiechl-Kohlendorfer, Ursula; Neubauer, Vera: The Effect of Postnatal Cytomegalovirus Infection on (Micro)structural Cerebral Development in Very Preterm Infants at Term-Equivalent Age.
NEONATOLOGY. 2023; 120(6); 727-735.
PubMed: 37634498 doi: 10.1159/000532084 [FLDID: 139499] IF: 2.600 (2023) / ZIT: 2

Sappler, Maria; Volleritsch, Nina; Hammerl, Marlene; Pellkofer, Yasmin; Griesmaier, Elke; Gizewski, Elke Ruth; Kaser, Susanne; Kiechl-Kohlendorfer, Ursula; Neubauer, Vera: Microstructural Brain Development and Neurodevelopmental Outcome of Very Preterm Infants of Mothers with Gestational Diabetes Mellitus.
NEONATOLOGY. 2023; 120(6); 768-775.
PubMed: 37643585 doi: 10.1159/000533335 [FLDID: 139416] IF: 2.600 (2023) / ZIT: 2

Hochmayr, Christoph; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke: COVID toes, newborn blue toes, and prepartum SARS-CoV-2 infection Reply.
LANCET. 2023; 402(10408); 1132-1132.
PubMed: 37777333 [FLDID: 140111] IF: 98.400 (2023) / ZIT: 0

Cardiovascular Science

Staudt, Anna; Kiechl, Sophia J.; Gande, Nina; Hochmayr, Christoph; Bernar, Benoit; Stock, Katharina; Geiger, Ralf; Egger, Alexander; Griesmacher, Andrea; Knoflach, Michael; Kiechl-Kohlendorfer, Ursula: Influence of Oral Contraceptives on Lipid Profile and Trajectories in Healthy Adolescents. Data From the EVA-Tyrol Study. JOURNAL OF ADOLESCENT HEALTH. 2024; 75(3); 479-486. PubMed: 39001754 doi: 10.1016/j.jadohealth.2024.04.017

NCD Risk Factor Collaboration [Kiechl-Kohlendorfer, U.; Kiechl, S.; Knoflach, M.; Pechlaner, R.; Ulmer, H.; Willeit, J.; Willeit, P.]: Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.
LANCET. 2024; 403(10431); 1027-1050. PubMed: 38432237 doi: 10.1016/S0140-6736(23)02750-2

Nairz, Johannes; Messner, Alex; Kiechl, Sophia J.; Winder, Bernhard; Hochmayr, Christoph; Egger, Alexander E.; Griesmacher, Andrea; Geiger, Ralf; Griesmaier, Elke; Pechlaner, Raimund; Knoflach, Michael; Kiechl-Kohlendorfer, Ursula; Early Vasc Ageing YOUth EVA4YOU.: Determinants of non-alcoholic fatty liver disease in young people: Maternal, neonatal, and adolescent factors.
PLOS ONE. 2024; 19(2); e0298800. PubMed: 38386674 doi: 10.1371/journal.pone.0298800

Mitterer, Wolfgang; Komazec, Irena Odri; Huber, Eva; Schaefer, Benedikt; Posod, Anna; Kiechl-Kohlendorfer, Ursula: Young hearts, early risks: novel cardiovascular biomarkers in former very preterm infants at kindergarten age. PEDIATRIC RESEARCH. 2024; [Epub ahead of print]; PubMed: 38658663 doi: 10.1038/s41390-024-03210-7

Messner, Alex; Nairz, Johannes; Kiechl, Sophia; Winder, Bernhard; Pechlaner, Raimund; Geiger, Ralf; Knoflach, Michael; Kiechl-Kohlendorfer, Ursula; EVA4YOU Tyrol Study Grp: Comparison of body mass index and fat mass index to classify body composition in adolescents-The EVA4YOU study.
EUROPEAN JOURNAL OF PEDIATRICS. 2024; 183(5); 2203-2214. PubMed: 38386029 doi: 10.1007/s00431-024-05474-x

Hoeck, Michaela; Posod, Anna; Odri Komazec, Irena; Griesmaier, Elke; Ralser, Elisabeth; Pupp-Peglow, Ulrike; Kiechl-Kohlendorfer, Ursula: Cardiac biomarkers and left ventricular systolic function in former very preterm infants and term controls at preschool age.
FRONTIERS IN PEDIATRICS. 2024; 12; 1376360.
PubMed: 38590770 doi: 10.3389/fped.2024.1376360 [FLDID: 142269] IF: 2.100 (2023) / ZIT: 0

Nairz, Johannes; Messner, Alex; Kiechl, Sophia J.; Winder, Bernhard; Hochmayr, Christoph; Granna, Julian; Egger, Alexander E.; Griesmacher, Andrea; Geiger, Ralf; Knoflach, Michael; Kiechl-Kohlendorfer, Ursula; Early Vascular Ageing in the YOUth Study Group: Prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and its association with arterial stiffness in adolescents: Results from the EVA4YOU study.
PLOS ONE. 2024; 19(11); e0314585.
PubMed: 39602440 doi: 10.1371/journal.pone.0314585 [FLDID: 144140] IF: 2.900 (2023) / ZIT: 0

NCD Risk Factor Collaboration [Kiechl-Kohlendorfer, U.; Kiechl, SJ.; Kiechl, S.; Knoflach, M.; Pechlaner, R.; Ulmer, H.; Willeit, K.; Willeit, P.]: Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants.
LANCET. 2024; 404(10467); 2077-2093.
PubMed: 39549716 doi: 10.1016/S0140-6736(24)02317-1 [FLDID: 144544] IF: 98.400 (2023) / ZIT: 82

NCD Risk Factor Collaboration [Kiechl-Kohlendorfer, U.; Kiechl, SJ.; Kiechl, S.; Pechlaner, R.; Willeit, K.; Willeit, P.]: General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants.
LANCET. 2024; 404(10455); 851-863.
PubMed: 39216975 doi: 10.1016/S0140-6736(24)01405-3 [FLDID: 144545] IF: 98.400 (2023) / ZIT: 13

Bernar, Benoit; Gande, Nina; Stock, Anna Katharina; Staudt, Anna; Pechlaner, Raimund; Hochmayr, Christoph; Kaltseis, Katharina; Winder, Bernhard; Kiechl, Sophia Julia J.; Broessner, Gregor; Geiger, Ralf; Kiechl, Stefan; Early Vasc Ageing EVA Tyrol Study Grp, Michael; Kiechl-Kohlendorfer, Ursula; Knoflach, Michael: Early Vascular Ageing in adolescents with migraine with aura: a community-based study.
BMC CARDIOVASCULAR DISORDERS. 2023; 23(1); 384.
PubMed: 37528337 doi: 10.1186/s12872-023-03409-2 [FLDID: 139620] IF: 2.000 (2023) / ZIT: 1

Gande, Nina; Hochmayr, Christoph; Staudt, Anna; Bernar, Benoit; Stock, Katharina J.; Kiechl, Sophia; Geiger, Ralf; Griesmacher, Andrea; Scholl-Burgi, Sabine; Knoflach, Michael; Pechlaner, Raimund; Kiechl-Kohlendorfer, Ursula; Early Vasc Ageing EVA Study Grp: Plasma homocysteine levels and associated factors in community-dwelling adolescents: the EVA-TYROL study.
FRONTIERS IN CARDIOVASCULAR MEDICINE. 2023; 10; 1140990.
PubMed: 37424916 doi: 10.3389/fcvm.2023.1140990 [FLDID: 139255] IF: 2.800 (2023) / ZIT: 1

Hochmayr, Christoph; Ndayisaba, Jean-Pierre; Gande, Nina; Staudt, Anna; Bernar, Benoit; Stock, Katharina; Kiechl, Sophia; Geiger, Ralf; Griesmaier, Elke; Knoflach, Michael; Kiechl-Kohlendorfer, Ursula; Early Vasc Ageing EVA Study Grp: Cardiovascular health profiles in adolescents being born term or preterm-results from the EVA-Tyrol study.
BMC CARDIOVASCULAR DISORDERS. 2023; 23(1); 371.
PubMed: 37488472 doi: 10.1186/s12872-023-03360-2 [FLDID: 139141] IF: 2.000 (2023) / ZIT: 2

Mueller, K.; Messner, A.; Nairz, J.; Winder, B.; Staudt, A.; Stock, K.; Gande, N.; Hochmayr, C.; Bernar, B.; Pechlaner, R.; Griesmacher, A.; Egger, AE.; Geiger, R.; Kiechl-Kohlendorfer, U.; Knoflach, M.; Kiechl, SJ.: Determinants of Diet Quality in Adolescents: Results from the Prospective Population-Based EVA-Tyrol and EVA4YOU Cohorts.
NUTRIENTS. 2023; 15(24); 5140.
PubMed: 38140399 doi: 10.3390/nu15245140 [FLDID: 141176] IF: 4.800 (2023) / ZIT: 1

NCD Risk Factor Collaboration [Kiechl-Kohlendorfer, U.; Kiechl, S.; Knoflach, M.; Pechlaner, R.; Ulmer, H.; Willeit, J.; Willeit, P.]: Diminishing benefits of urban living for children and adolescents’ growth and development.
NATURE. 2023; 615(7954); 874-883.
PubMed: 36991188 doi: 10.1038/s41586-023-05772-8 [FLDID: 137784] IF: 50.500 (2023) / ZIT: 33

NCD Risk Factor Collaboration [Kiechl-Kohlendorfer, U.; Kiechl, S.; Knoflach, M.; Pechlaner, R.; Ulmer, H.; Willeit, J.; Willeit, P.]: Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c.
NATURE MEDICINE. 2023; 29(11); 2885-2901.
PubMed: 37946056 doi: 10.1038/s41591-023-02610-2 [FLDID: 140564] IF: 58.700 (2023) / ZIT: 36

Neonatal Research Laboratory

Hochmayr, Christoph; Winkler, Ira; Hammerl, Marlene; Hoeller, Alexander; Huber, Eva; Urbanek, Martina; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke; Posod, Anna: Factors Influencing Breast Milk Antibody Titers during the Coronavirus Disease 2019 Pandemic: An Observational Study. NUTRIENTS. 2024; 16(14); 2320. PubMed: 39064762 doi: 10.3390/nu16142320

Hochmayr, Christoph; Toferer, Martha; Hammerl, Marlene; Winkler, Ira; Huber, Eva; Urbanek, Martina; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke; Posod, Anna: Breast milk anti-S1RBD immunoglobulin concentrations throughout lactation: An observational report.
ACTA PAEDIATRICA. 2024; 113(1); 81-83. PubMed: 37814794 doi: 10.1111/apa.16997

Posod, Anna; Wechselberger, Karina; Pellkofer, Yasmin; Hammerl, Marlene; Urbanek, Martina; Huber, Eva; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke: Investigation of secretoneurin as a potential biomarker of brain injury in very preterm infants: A pilot study.
PLOS ONE. 2023; 18(4); e0284096.

Mayer, E.; Winkler, I.; Huber, E.; Urbanek, M.; Kiechl-Kohlendorfer, U.; Griesmaier, E.; Posod, A.: Effects of DHEA and DHEAS in Neonatal Hypoxic-Ischemic Brain Injury.
ANTIOXIDANTS. 2024; 13(12); 1542.
PubMed: 39765870 doi: 10.3390/antiox13121542 [FLDID: 144269] IF: 6.000 (2023) / ZIT: 0

Posod, Anna; Wechselberger, Karina; Pellkofer, Yasmin; Hammerl, Marlene; Urbanek, Martina; Huber, Eva; Kiechl-Kohlendorfer, Ursula; Griesmaier, Elke: Investigation of secretoneurin as a potential biomarker of brain injury in very preterm infants: A pilot study.
PLOS ONE. 2023; 18(4); e0284096.
PubMed: 37023080 doi: 10.1371/journal.pone.0284096 [FLDID: 139480] IF: 2.900 (2023) / ZIT: 3

Transcription factor FOXO3 research group

Hausott, Barbara; Pircher, Lena; Kind, Michaela; Park, Jong-Whi; Claus, Peter; Obexer, Petra; Klimaschewski, Lars: Sprouty2 Regulates Endocytosis and Degradation of Fibroblast Growth Factor Receptor 1 in Glioblastoma Cells. CELLS. 2024; 13(23); 1967. PubMed: 39682716 doi: 10.3390/cells13231967

Salvador, Christina; Salvador, Robert; Kropshofer, Gabriele; Meister, Bernhard; Rock, Marie; Obexer, Petra; Hetzer, Benjamin; Rabensteiner, Evelyn; Crazzolara, Roman: Prophylaxis with enoxaparin and antithrombin III in drug-induced coagulation alterations in childhood leukemia: a retrospective experience of 20 years. THROMBOSIS JOURNAL. 2024; 22(1); 30. PubMed: 38539225 doi: 10.1186/s12959-024-00602-x

Podpeskar, Alexandra; Crazzolara, Roman; Kropshofer, Gabriele; Hetzer, Benjamin; Rabensteiner, Evelyn; Meister, Bernhard; Obexer, Petra; Salvador, Christina: Recommendations for Nutritional Supplementation in Pediatric Oncology: A Compilation of the Facts. NUTRIENTS. 2023; 15(14); 3239.
PubMed: 37513658 doi: 10.3390/nu15143239

Early vascular ageing (NeoVasC and EVA4YOU), part of the excellence initiative (Competence Centers for Excellent Technologies—COMET) of the Austrian Research Promotion Agency FFG: “Research Center of Excellence in Vascular Ageing—Tyrol, VASCage” (K project number 843536) of the Austrian Research Promotion Agency FFG (COMET program), funded by the Austrian Ministry for Transport, Innovation and Technology, the Austrian Ministry for Digital and Economic Affairs and the federal states Tyrol (via Standortagentur), Salzburg and Vienna (via Vienna Business Agency). 1,1 Mio. Euro

• NCD Risk Factor Collaboration – Imperial College London
• Gerhard Pichler, Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.
• Martin Lee, Prolacta Bioscience, Monrovia, CA
• Bea Latal, Child Development Centre, University Children’s Hospital Zurich, Switzerland
• Sven Wellemann, Department of Neonatology, University Children’s Hospital Regensburg, Germany
• Sampsa Vanhatalo, Department of Neurosciences, University of Helsinki, Finland
• Sara Tucci, University Medical Centre Freiburg, Germany
• Jan Kureck, TU Berlin, Germany
• Moon R, Goldberg Center for Community Pediatric Health, Children’s National Medical Center, Washington, US, and Blair PS, University of Bristol, UK (International Society for the Prevention of Infant Death)

Tollinger M, Institute of Organic Chemistry, CMBI- Centre for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria]